产品货号：
Z12128
中文名称：
BICD2抗体
英文名称：
Anti-BICD2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BICD2 Antibody |
| 指标别名 | SMALED2,bA526D8.1,KIAA0699,Protein bicaudal D homolog 2,Bic-D 2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB |
| 基因名称 | BICD2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | BICD2 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human BICD2.The immunogen is located within the last 50 amino acids of BICD2. |
| 计算分子量 | 94kDa |
| 成分 | BICD2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | BICD2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis.Similar to the highly homologous protein BICD1,BICD2 can bind to dynein-dynactin complex,primarily through the dynamitin subunit of dynactin.The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein,suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles.Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation,neurofilament swelling in proximal axons,etc.,suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients. |
| Uniprot ID | Q8TD16 |
| 基因名全称 | Bicaudal D homolog 2 (Drosophila) |
| 蛋白名全称 | Bicaudal D homolog 2 (Drosophila) |
| 推荐稀释比 | BICD2 antibody can be used for detection of BICD2 by Western blot at 1 ～ 2μg/mL.Antibody validated:Western Blot in human samples.All other applications and species not yet tested. |
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